Photo Credit: russ
"The Big Easy," as New Orleans is sometimes referred to, is located on the Mississippi River. It is the largest city in Louisiana. The city itself is actually below sea level, and it is believed to sink a little bit each year due to it location on next to the river and on swampland.
By far the most famous event in New Orleans is Mardi Gras, and the place most tourists head to first is Bourbon Street, located in the French Quarter. Even though Bourbon Street never sleeps and most places stay open all night, even if partying isn't your thing, strolling the Quarter during the day is a must, if for no other reason than to soak up some of the local culture and sample some excellent food. You can get great jumbalaya, gumbo, and other creole specialties at most places.
UPDATE: New Orleans has recently been devastated by Hurricane Katrina. Much of the city is under many feet of water as a result of levee breaks which allowed waters from Lake Pontchartrain to flood the low lying city. The city is currently out of commission and in chaos, as people are desperate for food and water, and the situation has caused looting and violence.